Status | Administered Cell Population | Recipient’s Spleen Cell Populations | ||||||
CD3 | CD4 | CD8 | B220 | GR1 | T reg | Thy1 | ||
Post BMT | Control, No MMSC | 29.6 ± 2.1 | 16.2 ± 3.6 | 13.7 ± 1.3 | 51.9 ± 5.9 | 18.7 ± 3.0 | 3.1 ± 0.7 | NA |
Post BMT | Primary 105 MMSC cells | 22.4 ± 2.1 * | 13.9 ± 0.6 NS | 14.1 ± 3.5 NS | 49.9 ± 8.2 NS | 18.8 ± 9.4 NS | 4.3 ± 1.0 NS | NA |
Post BMT | 105 OMA-AD MSC cells | 15.5 ± 4.0 * | 8.8 ± 1.9 * | 26.0 ± 11.2 * | 41.0 ± 14.5 NS | 18.6 ± 8.3 NS | 3.8 ± 1.0 NS | NA |
Survival Date, Post MMSC | Primary MMSC 1 × 105 cells | ND | 48.2 ± 7.7 ** | 24.6 ± 5.5 * | 18.5 ± 17.7 ** | ND | 5.8 ± 1.3 * | NA |
Survival Date, Post MMSC | OMA-AD 1 × 105 cells | ND | 61.2 ± 17.3 ** | 26.0 ± 11.2 * | 18.7 ± 17.7 * | ND | 4.8 ± 1.8 NS | NA |
Post BMT, with L1210 cells | No MMSC cells | 1.38 *** | 0.001 *** | 0.47 *** | 0.23 *** | ND | ND | 86.5 *** |